Note (September 2026): This guide now reflects Newsweek’s 2026 ranking and CMS’s 2024 spending data. Earlier versions misstated Cleveland Clinic’s…
Note (September 2026): Earlier versions of this list included FirstGroup America, a transportation company rather than a staffing firm, and…
Note (September 2026): Several facts in the original list were wrong: Visa never completed its purchase of Plaid (the deal…
Note (September 2026): Several facts in the original list were wrong or out of date, including McKesson’s founding date and…
Note (September 2026): This list has been updated. The original definition of SaaS, the Zoho product descriptions (Zoho Survey and…
Note (September 2026): The original version wrongly called Microsoft the oldest company on this list and the most valuable in…
Note (September 2026): This list has been corrected: Johnson & Johnson’s consumer brands now belong to Kenvue, Kraft Foods Group…
Leading cybersecurity companies headquartered in the USA include Palo Alto Networks (revenue about $11.5 billion in fiscal 2026), Fortinet ($6.80…
Note (September 2026): Several facts in the original article were out of date or wrong. Anthem is now Elevance Health,…
The largest cloud computing companies in the USA are Amazon Web Services (AWS), Microsoft Azure and Google Cloud. According to…
Note (September 2026): Fly.io no longer gives new customers a free allowance (it ended on October 7, 2024), and Vercel’s…
To protect your business, secure its data (multi-factor authentication, updates, backups, encryption and shredding), train staff to spot phishing and…